Poster Presentation ANZTS Trauma 2024 Conference

Predictors of Health-Related Quality of Life among Major Trauma Patients Discharged from Hospitals. A Systematic Review and Meta-analysis (21582)

Zemedu Ferede 1 2 , Vignesh Raman 1 , Arpita Das 1 2 , Silvia Manzanero 1 2 , Jeffrey Lipman 2 3 , Justin Kenardy 2 4 , Beat Schmutz 2 5 , Michael Schuetz 1 2 , Dylan Flaws 2 3 6
  1. School of Clinical Science, Queensland University of Technology, Brisbane, Qld, Australia
  2. Jamiesson Trauma Institute, Metro North Health, Herston/ Brisbane, Qld, Australia
  3. Faculty of Medicine, Brisbane, QLD, Australia , The University of Queensland, Brisbane, Qld, Australia
  4. School of Psychology, , The University of Queensland, Brisbane, Qld, Australia
  5. School of Biomedical engineering, Queensland University of Technology, Brisbane, Qld, Australia
  6. Department of Mental Health, Caboolture Hospital, Metro North Health, Caboolture, Qld, Australia

Introduction: Advancements in trauma systems enhance survival rates while post-discharge quality of life remains a challenge. Studying predictors of Health-Related Quality of Life (HRQOL) is crucial for enhancing trauma recovery outcomes.

Methods: PubMed, Embase, Scopus, Cochrane Library, and CINAHL were searched. The focus of the study was HRQOL, and studies with multiple predictor variables were included. Only studies involving participants who were 18 years or older, and Injury Severity Score (ISS) ≥ 12 were considered. The risk of bias was assessed using Quality in Prognosis Studies (QUIPS).

Result: From total of 12,063 articles assessed thirteen studies were included. Overall, only one study was low-risk, while the rest were moderate-risk.  Increasing age was associated with lower Physical Component Score (PCS) and higher Mental Component Score (MCS) on SF-36. Female sex predicted lower MCS with pooled odds ratio 1.94 (95% CI 1.26-2.62, I2 0%, p<0.001).   Comorbidity measured by severity American Society of Anesthesiology (ASA) score predicted lower HRQOL (pooled beta -0.09 (-0.13- -0.04, I2 0%, P<0.001), while psychiatric comorbidity predicted low HRQOL, particularly in MCS. High ISS score predicted poor HRQOL. Longer time after injury predict poor MCS, but improved PCS. Multiple injury predicted poor PCS, while it is inconclusive to determine the effect of head injuries.

Conclusion: Increasing age predicted lower PCS and higher MCS. Female sex, psychiatric comorbidity, and long days since injury predicted lower MCS, while higher ASA and ISS scores predicted lower EQ-5D. Long days since injury predicted higher PCS, while multiple injuries predicted lower PCS.